אינדקס
Vitamin D dose
מחקר ענק בארה"ב ספרד ובריטניה גילה שויטמין מונע מלחמלות מקורונה וגם מסייע בהחלמה-מנה מומלצת 1000U
25DC
VITAMIN D3-10000U לפחות 1000U
500MG VITAMIN C
אבץ
אלה עוזרים להחליף מוירוס הקורונה אבל גם יכלים למנוע קורונה אם יש מינון גבוהה מהם בגוף ובמחזור הדם
Vitamin D, First clinical trial
Please share this video around, this message needs to get out there, thank you, John
https://www.healthline.com/nutrition/...
About 42% of the US population is vitamin D deficient
82% in black people
70% in Hispanics
Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results, (JAMA Open, 3rd September, Chicago)
https://jamanetwork.com/journals/jama...
Cohort study of 489
Patients who had a vitamin D level measured in the year before COVID-19
testing
Relative risk of testing positive for COVID-19 was 1.77 times
First clinical trial on vitamin D and COVID
Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study" (Spain, Journal of steroid biochemistry and molecular biology)
https://www.sciencedirect.com/science...
Objective
Vitamin D decreases Acute Respiratory Distress Syndrome
Effect of calcifediol treatment
Calcifediol can rapidly increase serum 25OHD concentration
25-hydroxyvitamin D
Intensive Care Unit Admission and Mortality
Spanish patients hospitalized for COVID-19.
Design
Parallel pilot, randomized, double-masked clinical trial
Setting
Reina Sofia University Hospital, Córdoba, Spain
Participants
76 consecutive patients hospitalized with COVID-19 infection
Clinical picture of acute respiratory infection
Confirmed by a radiographic pattern of viral pneumonia
Positive SARS-CoV-2 PCR
Procedures
All hospitalized patients received as best available therapy
Hydroxychloroquine and azithromycin
Allocated at a 2 calcifediol:1
Oral calcifediol (0.532 mg), or not
Oral calcifediol (0.266 mg) on day 3 and 7
Then weekly until discharge
End points, ICU admission and deaths.
Results
50 patients treated with calcifediol
One required admission to the ICU (2%),
Of 26 untreated patients, 13 required admission (50%)
p less than 0.001
Of the patients treated with calcifediol, none died, and all were discharged, without complications
Of the patients not treated, 2 died
Conclusion
Calcifediol seems to be able to reduce severity of the disease
Larger trials with groups properly matched will be required to show a definitive answer
Rationale, activation of the vitamin D receptor (VDR) signalling pathway
Reduced ARDS
Cytokine/chemokine storm
Regulating the renin angiotensin system
Modulating neutrophil activity
Maintaining the integrity of the pulmonary epithelial barrier
Stimulating epithelial repair
Tapering down the increased coagulability
Ventilate
Don't abdicate
Dilute that virus
So you stay great
Ventilate
Don't complicate,
Complain or whine
You'll acclimate
Contemplate
When you congregate
Does the air here circulate
Instigate, Nominate
Educate, Motivate
I hope this message will resonate
That when we populate
Instead of isolate
Ventilate
Don't abdicate
Dilute that virus
So you stay great
Vitamin D, NAC, Zinc, and Vitamin C will help against a lot of alignments
take 2 Vitamin D3 total 10,000 iu and for the rest I take recommended dosages that are on the bottle
10,000 a day. Do 1,000 Vitamin C and more Zinc. Nac as directed. K2 is Vitamin K. Take as directed. K2 helps absorb the Vitamin D3
better not to exceed 15 mg of zinc unless you have respiratory symptoms (or maybe test positive). If you have respiratory symptoms, then 50 mg per day. Otherwise the extra zinc will give you the sore throat, congestion feelings (personal experience from making the mistake, then researching correct dose).
New Study on Vitamin D and Latitude Powerful Effects on Viral Dangers?
reveals the more nuanced interactions between Vitamin D, Latitude, UV and the impacts of Covid19 on different countries around the globe. Note that there's more to the sun than Vitamin D - there's Nitric Oxide and more too! We know that there is a strong seasonal effect with Covid19 already - Northern Hemisphere (Europe/USA) hit really hard coming out of their winter, while Southern hemisphere (Australia/NZ) getting away with incredibly low impacts. But what about countries nearer the equator - what will happen to them - and WHEN? GUEST DETAILS: Rahul KM ( Rahul Thondan) Faculty of Economics & Business, Goethe University - Frankfurt Founder : http://forecasty.ai Contact : rahulkm85@gmail.com Rahul on Twitter here - follow him! https://twitter.com/rahulthondan Rahul's Study here: https://papers.ssrn.com/sol3/papers.c...
The D-Lightful Vitamin D for Health by Michael F. Holick
Since 1950, the University Lecture has offered members of the BU community and the general public an opportunity to hear from distinguished faculty about the outstanding and often groundbreaking research and scholarship in which they are actively engaged. The 2013 University Lecture titled, The D-Lightful Vitamin D for Health was presented by Michael F. Holick, PhD, MD, Professor of Medicine, Physiology and Biophysics at the Boston University School of Medicine.
Vitamin D – State of the art“ - Dr. Michael F. Holick in Viennathe Biogena Academy invited the American Vitamin D expert to Vienna . Dr. Michael F. Holick explains in his presentation important information and facts about the valuable vitamin. This lecture formed the basis of subsequent discussion, with other experts of this special field. The whole lecture " Vitamin D - State of the art " you can watch online here
The Pandemic and Vitamin D, Science
Scientific Advisory Committee on Nutrition (SACN)
https://www.gov.uk/government/groups/...
SACN vitamin D and health report
https://www.gov.uk/government/publica...
A reference nutrient intake (RNI) of 10 micrograms (400 units) of vitamin D per day, throughout the year, for everyone in the general population aged 4 years and older
The RNI and safe intakes were developed to ensure that the majority of the UK population has enough vitamin D to protect musculoskeletal health, all year round.
SACN did not take account of sunlight exposure in making recommendations because of the number and complexity of factors that affect skin synthesis of vitamin D.
Vitamin D
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (2011)
The Endocrine Society
https://www.endocrine.org
Journal of Clinical Endocrinology
https://pubmed.ncbi.nlm.nih.gov/21646...
Vitamin D deficiency is very common in all age groups
Few foods contain vitamin D
Task Force recommended supplementation, depending on age and clinical circumstances
Measurement of serum 25-hydroxyvitamin D level, in patients at risk for deficiency
Treatment with supplement recommended for deficient patients
https://www.healthline.com/nutrition/...
About 42% of the US population is vitamin D deficient
82% in black people
70% in Hispanics
Nutrients, 15 July 2020
https://www.mdpi.com/2072-6643/12/7/2097
Immunologic Effects of Vitamin D on Human Health and Disease
Calcium and phosphate metabolism, bones
1,25-dihydroxyvitamin D, active form of vitamin D
Immunomodulatory hormone
Innate and adaptive immune systems
Vitamin D receptor and enzymes in;
Lymphocytes
NKs
T lymphocytes
B lymphocytes
Monocytes
Macrophages
Dendritic cells
Vascular endothelial membrane stability
Association with low blood levels of 25-hydroxyvitamin D
Several immune-related diseases and disorders
Psoriasis,
Type 1 diabetes
Multiple sclerosis
Rheumatoid arthritis
Tuberculosis
Sepsis
Respiratory infection
COVID-19
Optimal Serum 25-hydroxyvitamin D
It is advisable to increase vitamin D intake and have sensible sunlight exposure
Maintain serum 25-hydroxyvitamin D at least,
30 ng/mL (75 nmol/L)
and preferably
40–60 ng/mL (100–150 nmol/L)
Recommended dosage for vitamin D intake in individuals who are at risk for vitamin D
Deficiency (1,000 iu = 25 mcg)
Age, years Daily requirement Upper limit
Years Requirement
0 – 1 400 – 1,000 2,000
1 – 18 600 – 1,000 4,000
18 + 1500- 2000 10,000
Obese 4,000 – 6000 10,000
For deficiency 0 – 1 year
2000 IU/day or 50,000 IU/week
of vitamin D2 or D3 for at least 6 weeks
to achieve serum 25(OH)D more than 30 ng/mL (75 nmol/L)
maintenance therapy of 400–1000 IU/d
For deficiency 1 – 18 years
2000 IU/day or 50,000 IU/week of vitamin D2 or D3 for at least 6 weeks
to achieve serum 25(OH)D more than 30 ng/mL (75 nmol/L)
maintenance therapy of 600–1000 IU/d
For deficiency after 18 years
6000 IU/day or 50,000 IU/week
of vitamin D2 or D3 for 8 weeks
to achieve serum 25(OH)D more than 30 ng/mL (75 nmol/L)
maintenance therapy of 1500 –2000 IU/d
Obese and malabsorptive patients
Dosage should be increased by 2–3 times
Respiratory Viral Infection and COVID-19
Outbreak of influenza infection is periodic and usually occurs during the wintertime at higher latitudes
but is sporadic throughout the year in the tropical area
Association between low level of serum 25(OH)D and
incidence and severity of respiratory tract infection in children and adults
A recent meta-analysis of 25 RCTs showed that supplementation of vitamin D2 or D3 can protect against the development of acute respiratory tract infection compared with placebo
https://www.bmj.com/content/356/bmj.i...
COVID
Rate of symptomatic infection, morbidity and mortality observed
African American
Obesity
Worldwide on average approximately 40% of children and adults have circulating levels of 25(OH)D less than 20 ng/mL (50 nmol/L)
It is therefore reasonable to institute as a standard of care to give at least one single dose of 50,000 of vitamin D to all COVID-19 patients as soon as possible after being hospitalized
Vitamin D Update
Vitamin D and Covid-19
Press release from the French National Academy of Medicine 22 May 2020
http://www.academie-medecine.fr/wp-co...
Vitamin D is a prohormone
Synthesized in the dermis under the effect of ultraviolet light
Transported to the liver and kidneys, where it is transformed into an active hormone
Responsible for intestinal absorption of calcium and bone health.
Modulates the functioning of the immune system by stimulating macrophages and dendritic cells
Role in regulating and suppressing the cytokine inflammatory response
Acute respiratory distress syndrome
A significant correlation between low serum vitamin D levels and mortality from Covid- 19
This phenomenon follows a North-South gradient
Exceptions are Nordic countries, vitamin D supplementation
Not a preventive or a therapeutic
By mitigating the inflammatory storm and its consequences, considered as an adjunct to any form of therapy.
Simple and inexpensive measure
Confirms its recommendation to ensure vitamin D supplementation in the French population
Recommends the rapid serum vitamin D (i.e. 25 OHD) testing in people over 60 years of age with Covid-19
Loading dose of 50,000 to 100,000 IU in case of deficiency, which could help limit respiratory complications;
Recommends vitamin D supplementation of 800 to 1000 IU/day in people under 60, as soon as the diagnosis of Covid-19 is confirmed.
Vitamin D: A Low-Hanging Fruit in COVID-19? (Medscape)
https://www.medscape.com/viewarticle/...
Observational data from various countries suggest inverse links;
Severity of COVID-19 responses
Mortality
No randomized controlled trial
Having adequate vitamin D is important, especially for those at the highest risk of COVID-19
No role
Simply a marker
A causal factor
Spain and northern Italy, high rates of vitamin D deficiency
Spain and Italy not formally fortify foods or recommend supplementation
Norway, Finland, and Sweden had higher vitamin D levels
European countries, P = .046, 95.4% confidence, (4.6% chance this result arose by chance)
Correlation is not causality
Optimizing vitamin D status to recommendations by national and international public health agencies will certainly have, potential benefits for COVID-19 (Irish Medical Journal), http://imj.ie/vitamin-d-and-inflammat...
Immune Modulation
https://www.medrxiv.org/content/10.11...
Data from China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, United Kingdom, United States
Risk of severe COVID-19
Vitamin D deficiency was 17.3%
Normal Vitamin D level was 14.6%
(a reduction of 15.6%).
Ethnic Minorities Disproportionately Affected
British Association of Physicians of Indian Origin (BAPIO) to get their vitamin D levels tested.
LARGE, SINGLE-DOSE, ORAL VITAMIN D SUPPLEMENTATION IN ADULT POPULATIONS: A SYSTEMATIC REVIEW
https://www.ncbi.nlm.nih.gov/pmc/arti...
They suggest a booster dose of 100,000 IU as a one-off
Single vitamin D3 doses ≥300,000 IU are most effective at improving vitamin D status…for up to 3 months
Daily doses of 1000 IU seem reasonable
Testing and Governmental Recommendations During COVID-19
US National Institute of Health
https://ods.od.nih.gov/factsheets/Vit...
400 IU to 800 IU per day, will result in blood levels that are sufficient to maintain bone health and normal calcium metabolism in healthy people
Public Health England (PHE)
https://www.nhs.uk/conditions/vitamin...
There is not sufficient evidence to support recommending Vitamin D for reducing the risk of COVID-19 (PHE)
https://derbynews.org.uk/2020/06/09/c...
Vitamin D Measurement the Key to Change
(Visit: http://www.uctv.tv) Alexander Wunsch, MD, Wismar University of Applied Sciences, Germany, discusses the importance of measurement when studying vitamin D. Michael F. Holick, PhD MD, Boston University Medical Center, discusses how to treat patients at rick for vitamin D deficiency. Recorded on 12/10/2014. [2/2015] [Show ID: 29085]
Vitamin D for Public Health - Integrating Sunshine, Supplements and Measurement for Optimal Health 2014
(https://www.uctv.tv/vitamin-d-public-...)
Explore More Health & Medicine on UCTV
(https://www.uctv.tv/health)
UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.
Vitamin D Toxicity Rare in People Who Take Supplements, Mayo Clinic Researchers Report
Over the past decade, numerous studies have shown that many Americans have low vitamin D levels and as a result, vitamin D supplement use has climbed in recent years. Vitamin D has been shown to boost bone health and it may play a role in preventing diabetes, cancer, cardiovascular disease and other illnesses. In light of the increased use of vitamin D supplements, Mayo Clinic researchers set out to learn more about the health of those with high vitamin D levels. They found that toxic levels are actually rare.
Their study appears in the May issue of Mayo Clinic Proceedings. For more information, see the Mayo Clinic News Network: http://newsnetwork.mayoclinic.org/
How Much Vitamin D3 Is Too Much? Your Vitamin D3 Daily Intake Based On The Research
VITAMIN D | Why Vitamin D is essentially useless unless you fix Insulin resistance - by Robert Cywes
Results of a Prostate Cancer/Vitamin D Trial: Effectiveness Safety Recommendations
Bruce W. Hollis, PhD, Medical University of South Carolina shares the results of a recent trial including identifying the vitamin D level needed to protect the prostate gland. Recorded on 12/09/2014. [3/2015] [Show ID: 29079]
Vitamin D for Public Health - Integrating Sunshine, Supplements and Measurement for Optimal Health 2014
(https://www.uctv.tv/vitamin-d-public-...)
Vitamin D dose
International units or micrograms
1,000 micrograms (mcg) in a milligram (mg)
1,000 milligrams (mg) in a gram (g)
1,000 grams in a kilogram (Kg)
1 kg is 2.2 pounds
IU mcg
400 10mcg
800 20mcg
1,000 25mcg
2,000 50mcg
4,000 100mcg
https://www.healthline.com/nutrition/...
US
42% of people have a vitamin D deficiency
82.1% of black people
69.2% of Hispanic people.
Higher blood levels = over 33 ng/ml or 82.4 nmol/l
Lower blood levels less than 12 ng/ml or 30 nmol/l
50% lower risk of colorectal cancer
Consuming 1,000 IU (25 mcg) daily would help 50% of people reach a vitamin D blood level of 33 ng/ml (82.4 nmol/l)
Consuming 2,000 IU (50 mcg) daily would help nearly everyone reach a blood level of 33 ng/ml (82.4 nmol/l)
Taking 1,000 IU (25 mcg) of vitamin D daily reduced heart disease risk by 10%
Consuming 1,000–4,000 IU (25–100 mcg) of vitamin D daily should be ideal for most people to reach healthy vitamin D blood levels.
However, don’t consume more than 4,000 IU of vitamin D without your doctor's permission. It exceeds the safe upper limits of intake and is not linked to more health benefits
https://link.springer.com/article/10....
https://link.springer.com/article/10....
https://www.bmj.com/content/356/bmj.i...
https://www.medrxiv.org/content/medrx...
https://www.medrxiv.org/content/10.11...
https://papers.ssrn.com/sol3/papers.c...
https://www.nature.com/articles/s4143... (pdf link)
https://endocare.hu/wp-content/upload... (pdf link)
https://tilda.tcd.ie/publications/rep... (p
https://www.thelancet.com/journals/la...
נערך לאחרונה על-ידי suceret בתאריך Mon Sep 07, 2020 4:07 pm, סך-הכל נערך 3 פעמים
