אינדקס
COVID-19: Poor outcomes in patients with zinc deficiency
https://www.sciencedirect.com/science/article/pii/S120197122030730X
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Patients with coronavirus disease 2019 (COVID-19) had significantly low zinc levels in comparison to healthy controls.
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Zinc deficient patients developed more complications (70.4% vs 30.0%, p = 0.009).
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Zinc deficient COVID-19 patients had a prolonged hospital stay (7.9 vs 5.7 days, p = 0.048).
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In vitro studies have shown that reduced zinc levels favour the interaction of angiotensin-converting enzyme 2 (ACE2) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and likewise that increased zinc levels inhibit ACE2 expression resulting in reduced viral interaction.
https://www.sciencedirect.com/science/article/pii/S120197122030730X
Highlights
•
Patients with coronavirus disease 2019 (COVID-19) had significantly low zinc levels in comparison to healthy controls.
•
Zinc deficient patients developed more complications (70.4% vs 30.0%, p = 0.009).
•
Zinc deficient COVID-19 patients had a prolonged hospital stay (7.9 vs 5.7 days, p = 0.048).
•
In vitro studies have shown that reduced zinc levels favour the interaction of angiotensin-converting enzyme 2 (ACE2) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and likewise that increased zinc levels inhibit ACE2 expression resulting in reduced viral interaction.
